Impairment of hepatic drug metabolism in alcoholics.

Gross impairment of hepatic drug metabolism in a patient with chronic liver disease.

Cognitive Impairment in Children of Alcoholics

ing • Adopted COAʼs have poorer ability (Ref. 1) and Planning • Alcoholic COAʼs (vs. FHN alcoholics) have poorer ability (Refs. 1,3,4) • Generally, COA-FHN differences are relatively small but are present (Refs. 2–4) 1The findings are presented for COAʼs compared with family history-negative subjects except where indicated. SOURCES: References (1) Tarter et al. 1990; (2) Sher 1991; (3) Pihl et ...

Circadian variation of ethanol metabolism in alcoholics.

The rate of ethanol metabolism was determined for 20 alcoholics during ajiemoon and evening drinking sessions on two consecutive days. Alcoholics demonstrated a faster rate of ethanol metabolism in the evening as compared to the afternoon, suggesting a circadian variation in the rate of ethanol metabolism. Previous drinking on the first day appeared to increase the rate of ethanol metabolism on...

Changes in hepatic drug metabolism in alloxan-diabetic male rabbits.

1. A. H. Conney, Pharmuc. Rev. 2. R. Kato. Drug Metah. Rev. 3. 3. .I. i3. Schenkman, I. Frey. H 19.317 (1967). l(1974). Remmer and R. W. Estabrook, Molec. Pharmac. 3.‘516 (1967). 4. R. Kato and M. Takayanaghi. Jup. J. Pharmac. 16,380 (1966). 5. B. R. Sonawane, S. J. Yaffe and B. H. Shapiro. Drq Merab. Dispos. I. 444 (1979). 6. D. M. Valerino, E. S. Vesell. A. 0. Johnson and K. C. Aurori. Drug M...

Endotoxin depresses hepatic cytochrome P450-mediated drug metabolism in women.

AIMS In men, the inflammatory response to intravenous endotoxin depresses apparent oral clearances of antipyrine, hexobarbitone, and theophylline. The aim of this study was to investigate whether there might be gender differences in the regulation of hepatic cytochromes P450. METHODS Experiments were carried out in seven healthy women volunteers (ages 19-51, median 22 years). Each woman recei...